Ionic currents responsible for the generation of pace-maker current in the rabbit sino-atrial node.
نویسندگان
چکیده
منابع مشابه
تأثیــر نیکــل بر مسدود کردن جریان یونــی گذرای کلسیمــی سلولهای گــره سینوسی ـ دهلیزی دست نخورده و سالم قلب خرگوش
The mammalian sino-atrial node is not a uniform tissue in histological and electrophysiological terms. The differences in ionic currents underlying the regional differences in electrial activity are only just beginning to be understood. One of the ionic currents it is thought to play a role in the center of sino-atrial node for action potential upstroke should be transient Ca+2 current ...
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Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
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15 صفحه اولSino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels.
The cardiac pacemaker is a sino-atrial (SA) nodal cell. The signal induced by this pacemaker is distributed over the heart surface by a specialised conduction system and is clinically recorded as the ECG. The SA nodal cells are highly resistant to cardiac failure and ischemia. Under calcium overload conditions, some dysrythmias of SA nodal cells occur easily. Morphological analysis under these ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1984
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1984.sp015415